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In a nutshell, the drug (known formally as fluoxetine or Citalopram hydrobromide) affects one of the neurotransmitters in brain, noradrenaline, to increase mood and promote sleep. So, in theory, fluoxetine should bring on a more positive mood, even though it is, itself, an antidepressant.
However, as with most studies, these results came from one trial involving only treatment group.
The main problems with this "small study" of fluoxetine are that:
There is some controversy about the way results can be interpreted – the researchers seem to have had a hard time getting sufficient statistical power in their study; they didn't control for other, more significant factors that could influence the results of study; and they made one critical error.
These problems are enough, however, that there is a fair amount of scepticism about fluoxetine (and similar drugs) in general. You can read all the details in my article Fluoxetine: The Best-Selling Drug In World (and Why It's Dangerous to You).
When you look for a "big, beautiful" double-blind, placebo-controlled study with a sample size of 200 and more – to be used bolster the findings in a later and larger study – that will give you a strong "positive" result, there are no more trials available.
You may have heard of an earlier research initiative where "several well-researched drugs" were tested across a wide variety of populations, including different ethnic groups, with "dramatic" results:
"Corticosteroids are among the most common and well-studied prescription drugs. In a landmark trial, the combination of aspirin with a corticosteroids significantly lowered the risk of developing cardiovascular events compared with aspirin alone" (Journal of the American Medical Association 1996, 297, 1845-1852).
"The Amitriptyline 50mg $103.63 - $0.38 Per pill combination of corticosteroids with aspirin has been shown to be as clinically superior aspirin alone, lowering cardiovascular disease, stroke and death" (International Journal of Cardiology 2004, 48, 797-804).
In short, there were "many" successful trial results with different drug preparations, each several combinations.
But what would happen, if we applied this same scientific method to a study of fluoxetine in children?
"For the first time, clinical trials of fluoxetine in children are available. Two doses of 1.75 or 2 mg have been studied in a placebo-controlled, double-blind, phase 3 study" (ClinicalTrials.gov, 2006).
This new study was not able to find significant beneficial effects on cognitive or affective functioning. It did find that fluoxetine was effective in improving sleep, however, but these effects were only seen in children aged 12 – 18 (ages the clinical study Orlistat generico faz efeito is only interested in).
The study could not find fluoxetine to be helpful in preventing the depression or suicidal behaviours we have come to expect from fluoxetine.
You can read more in my review of these clinical trials.
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